Acceptor site recognition of transglycosylase inhibitors -: A β-D-glucopyranosyl-(1→2)-α-D-glucopyranuronamide-derived moenomycin analogue

被引：11

作者：

Ferse, FT

Floeder, K

Hennig, L

Findeisen, M

Welzel, P

Müller, D

van Heijenoort, J

机构：

[1] Univ Leipzig, Fak Chem & Mineral, D-04103 Leipzig, Germany

[2] Ruhr Univ Bochum, Fak Chem, D-44780 Bochum, Germany

[3] Univ Paris 11, F-91405 Orsay, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 12期

关键词：

antibiotics; carbohydrates; phospholipids; structure-activity;

D O I：

10.1016/S0040-4020(98)01181-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis, the antibiotic and the transglycosylase inibiting properties of a disaccharide analogue of moenomycin A in which the NHAc group of unit E is replaced by a hydroxyl function are described. It can be concluded that this NHAc group is essential for eliciting transglycosylase inhibiting properties, in agreement with a recently established solution structure of moenomycin A. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3749 / 3766

页数：18

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