Design, synthesis and biological activity of a pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid

被引：32

作者：

Baraldi, PG ^{[1
]}

Cacciari, B

Guiotto, A

Leoni, A

Romagnoli, R

Spalluto, G

Mongelli, N

Howard, PW

Thurston, DE

Bianchi, N

Gambari, R

机构：

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Pharmacia & Upjohn Inc, Oncol, Preclin Res, Milan, Italy

[3] Portsmouth Polytech, Sch Pharm & Biomed Sci, CRC, Gene Targeted Drug Design Res Grp, Portsmouth PO1 2DT, Hants, England

[4] Univ Ferrara, Dipartmento Biochim & Biol Mol, I-44100 Ferrara, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(98)00544-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3019 / 3024

页数：6

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