Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS

被引：62

作者：

Ikejiri, Y

Mori, E

Ishii, K

Nishimoto, K

Yasuda, M

Sasaki, M

机构：

[1] HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV NEUROIMAGING RES,HIMEJI,HYOGO 670,JAPAN

[2] HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV BASIC NEUROSCI,HIMEJI,HYOGO 670,JAPAN

来源：

NEUROLOGY | 1996年 / 47卷 / 02期

关键词：

D O I：

10.1212/WNL.47.2.583

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q(10), increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.

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页码：583 / 585

页数：3

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