The role of the RNAi machinery in heterochromatin formation

被引：159

作者：

Wassenegger, M ^{[1
]}

机构：

[1] RLP AgroSci GmbH, AlPlanta Inst Plant Res, D-67435 Neustadt, Germany

来源：

CELL | 2005年 / 122卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.06.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considerable effort has been devoted to the characterization of RNA interference (RNAi), a posttranscriptional gene silencing mechanism involving small RNA-containing effector complexes. Recent studies have revealed that components of the RNAi machinery are associated not only with target RNA cleavage and impairment of target RNA translation but also with the formation of heterochromatin. There is increasing evidence that RNA-mediated chromatin modifications play an important role in epigenetic transcriptional gene silencing.

引用

页码：13 / 16

页数：4

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