Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection

被引：13

作者：

Alves, Marco P. ^{[1
,2
]}

Vielle, Nathalie J. ^{[1
,2
,3
]}

Thiel, Volker ^{[1
,2
]}

Pfaender, Stephanie ^{[1
,2
]}

机构：

[1] Inst Immunol & Virol, CH-3012 Bern, Switzerland

[2] Univ Bern, Vetsuisse Fac, Dept Infect Dis & Pathobiol, CH-3012 Bern, Switzerland

[3] Univ Bern, Grad Sch Cellular & Biomed Sci, CH-3012 Bern, Switzerland

来源：

VIRUSES-BASEL | 2018年 / 10卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

Zika virus; antivirals; therapeutics; research models and tools; HUMAN PLACENTAL TROPHOBLASTS; PLURIPOTENT STEM-CELLS; FDA-APPROVED DRUG; BROAD-SPECTRUM; IN-VITRO; CEREBRAL ORGANOIDS; NS2B-NS3; PROTEASE; RNA-POLYMERASE; DENGUE VIRUS; GUINEA-PIG;

D O I：

10.3390/v10110593

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massive advances have been made regarding our understanding of clinical manifestations, epidemiology, genetic diversity, genomic structure and potential therapeutic intervention strategies. Nevertheless, treatment remains a challenge as there is no licensed effective therapy available. This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies.

引用

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