Innate immunity: Turning off natural killers

被引：5

作者：

Imboden, J ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO, CA 94143 USA

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(02)70667-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitory receptors specific for class I molecules of the major histocompatibility complex regulate the cytolytic activity of natural killer cells. Recent studies suggest that recruitment of the protein tyrosine phosphatase SHP-1 enables these receptors to block natural killing.

引用

收藏

页码：1070 / 1072

页数：3

相关论文

共 10 条

[1] Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor [J].

Burshtyn, DN ;

Scharenberg, AM ;

Wagtmann, N ;

Rajagopalan, S ;

Berrada, K ;

Yi, TL ;

Kinet, JP ;

Long, EO .

IMMUNITY, 1996, 4 (01) :77-85

[2]

CAMPBELL KS, 1996, IN PRESS J EXP MED

[3] THE ENIGMA OF THE NATURAL-KILLER-CELL [J].

GUMPERZ, JE ;

PARHAM, P .

NATURE, 1995, 378 (6554) :245-248

[4] SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY [J].

KARRE, K ;

LJUNGGREN, HG ;

PIONTEK, G ;

KIESSLING, R .

NATURE, 1986, 319 (6055) :675-678

[5] INHIBITION OF SELECTIVE SIGNALING EVENTS IN NATURAL-KILLER-CELLS RECOGNIZING MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I [J].

KAUFMAN, DS ;

SCHOON, RA ;

ROBERTSON, MJ ;

LEIBSON, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6484-6488

[6]

Olcese L, 1996, J IMMUNOL, V156, P4531

[7] SUPERANTIGEN-DEPENDENT, CELL-MEDIATED CYTOTOXICITY INHIBITED BY MHC CLASS-I RECEPTORS ON T-LYMPHOCYTES [J].

PHILLIPS, JH ;

GUMPERZ, JE ;

PARHAM, P ;

LANIER, LL .

SCIENCE, 1995, 268 (5209) :403-405

[8] OF ITAMS AND ITIMS - TURNING ON AND OFF THE B-CELL ANTIGEN RECEPTOR [J].

THOMAS, ML .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (06) :1953-1956

[9] BIOLOGY OF NATURAL-KILLER CELLS [J].

TRINCHIERI, G .

ADVANCES IN IMMUNOLOGY, 1989, 47 :187-376

[10]

YOKOYAMA WM, 1993, ANNU REV IMMUNOL, V11, P613, DOI 10.1146/annurev.iy.11.040193.003145