HSP100/Clp proteins: A common mechanism explains diverse functions

被引：418

作者：

Schirmer, EC ^{[1
]}

Glover, JR ^{[1
]}

Singer, MA ^{[1
]}

Lindquist, S ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT MOL GENET & CELL BIOL, CHICAGO, IL 60637 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 08期

关键词：

D O I：

10.1016/0968-0004(96)10038-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.

引用

页码：289 / 296

页数：8

共 50 条

[11] A MEMBER OF THE CLPB FAMILY OF STRESS PROTEINS IS EXPRESSED DURING HEAT-SHOCK IN LEISHMANIA SPP
HUBEL, A
BRANDAU, S
DRESEL, A
CLOS, J
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 70 (1-2) : 107 - 118
[12] ESCHERICHIA-COLI CONTAINS A SOLUBLE ATP-DEPENDENT PROTEASE (TI) DISTINCT FROM PROTEASE LA
HWANG, BJ
PARK, WJ
CHUNG, CH
GOLDBERG, AL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) : 5550 - 5554
[13] INOUE I, 1994, J BIOL CHEM, V269, P29241
[14] KATAYAMA Y, 1988, J BIOL CHEM, V263, P15226
[15] HOMOLOGY IN STRUCTURAL ORGANIZATION BETWEEN ESCHERICHIA-COLI CLPAP PROTEASE AND THE EUKARYOTIC 26S-PROTEASOME
KESSEL, M
MAURIZI, MR
KIM, B
KOCSIS, E
TRUS, BL
SINGH, SK
STEVEN, AC
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1995, 250 (05) : 587 - 594
[16] CYSTOSOLIC CHAPERONIN SUBUNITS HAVE A CONSERVED ATPASE DOMAIN BUT DIVERGED POLYPEPTIDE-BINDING DOMAINS
KIM, S
WILLISON, KR
HORWICH, AL
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (12) : 543 - 548
[17] KRUGER E, 1994, J BACTERIOL, V176, P3360
[18] ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis
Kruklitis, R
Welty, DJ
Nakai, H
[J]. EMBO JOURNAL, 1996, 15 (04) : 935 - 944
[19] A SOYBEAN 101-KD HEAT-SHOCK PROTEIN COMPLEMENTS A YEAST HSP104 DELETION MUTANT IN ACQUIRING THERMOTOLERANCE
LEE, YRJ
NAGAO, RT
KEY, JL
[J]. PLANT CELL, 1994, 6 (12) : 1889 - 1897
[20] ADDICTION PROTEIN PHD OF PLASMID PROPHAGE P1 IS A SUBSTRATE OF THE CLPXP SERINE-PROTEASE OF ESCHERICHIA-COLI
LEHNHERR, H
YARMOLINSKY, MB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3274 - 3277

← 1 2 3 4 5 →