An efficient method for 4 beta-anilino-4'-demethylepipodophyllotoxins: Synthesis of NPF and W-68

被引：79

作者：

Kamal, A

Gayatri, NL

机构：

[1] Division of Organic Chemistry, Indian Inst. of Chemical Technology

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 19期

关键词：

D O I：

10.1016/0040-4039(96)00546-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4 beta-Substituted podophyllotoxin congeners have been obtained with significant stereoselectivity and improved yields by employing Bu(4)N(+)I(-) in the displacement reaction of the 4-bromoepipodophyllotoxin. The DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in good yields by this method. (C) 1996 Published by Elsevier Science Ltd

引用

页码：3359 / 3362

页数：4

共 18 条

[1] [Anonymous], 1980, ANTICANCER AGENTS BA
[2] ASYMMETRIC TOTAL SYNTHESIS OF (-)-PODOPHYLLOTOXIN
BUSH, EJ
JONES, DW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (15) : 1200 - 1201
[3] HITOSUYANAGI H, 1995, J CHEM SOC CHEM COMM, P49
[4] HITOSUYANAGI H, 1995, J CHEM SOC P1, P1387
[5] Kamal A, 1995, ANTI-CANCER DRUG DES, V10, P545
[6] A RAPID ENTRY INTO PODOPHYLLOTOXIN CONGENERS - SYNTHESIS OF JUSTICIDIN-B
KAMAL, A
DANESHTALAB, M
MICETICH, RG
[J]. TETRAHEDRON LETTERS, 1994, 35 (23) : 3879 - 3882
[7] MITOSIS INHIBITING NATURAL SUBSTANCES .23. A NEW METHOD OF GLYCOSIDATION .2. GLYCOSIDES OF 4'-DEMETHYLEPIPODOPHYLLOTOXIN
KUHN, M
VONWARTB.A
[J]. HELVETICA CHIMICA ACTA, 1969, 52 (04) : 948 - &
[8] LEE KH, 1993, ACS SYM SER, P170
[9] LETEURTRE F, 1992, CANCER RES, V52, P4478
[10] Macdonald T. L., 1991, DNA TOPOISOMERASES C, P199

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