B-cell development: a comparison between mouse and man

被引：100

作者：

Ghia, P

ten Boekel, E

Rolink, AG

Melchers, F

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(98)01330-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as thr lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

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页码：480 / 485

页数：6

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