Role of thrombopoietin in hematopoietic stem cell and progenitor regulation

被引:21
作者
Drachman, JG
机构
[1] Puget Sound Blood Ctr, Seattle, WA 98104 USA
[2] Univ Washington, Div Hematol, Seattle, WA 98195 USA
关键词
D O I
10.1097/00062752-200005000-00010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thrombopoietin performs an essential role during hematopoiesis by regulating the expansion and maturation of megakaryocytes. In keeping with this function, megakaryocytes, platelets, and their precursors ail express the thrombopoietin receptor, Mpl, on their cell surface. However, Mpl is also expressed on primitive, pluripotent hematopoietic progenitors and plays an important role in the regulation of lineages other than megakaryocytes as well as primitive progenitors. Recently, the ability of thrombopoietin to maintain and expand repopulating stem cells has been demonstrated. Thus, thrombopoietin is unique among the hematopoietic cytokines because it is necessary both for terminal maturation and regulation of lineage-specific megakaryocytes and also for maintenance of the most primitive hematopoietic stem cells, Many new strategies are evolving to exploit the activity of thrombopoietin on primitive progenitors. This may lead to faster hematopoietic recovery from marrow-suppressive therapy, effective methods of ex vivo expansion of hematopoietic stem cells, and retroviral transduction of stem cells to facilitate gene therapy. (C) 2000 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:183 / 190
页数:8
相关论文
共 81 条
[31]   Thrombopoietins and thrombopoiesis: A clinical perspective [J].
Kuter, DJ .
VOX SANGUINIS, 1998, 74 :75-85
[32]   THE PURIFICATION OF MEGAPOIETIN - A PHYSIOLOGICAL REGULATOR OF MEGAKARYOCYTE GROWTH AND PLATELET PRODUCTION [J].
KUTER, DJ ;
BEELER, DL ;
ROSENBERG, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :11104-11108
[33]   Human neonatal blood:: stem cell content, kinetics of CD34+ cell decline and ex vivo expansion capacity [J].
Li, K ;
Liu, J ;
Fok, TF ;
Yau, FW ;
Wong, A ;
Li, CK ;
Yang, M ;
So, KW ;
Chik, KW ;
Tsang, KS ;
Shing, MMK ;
Yuen, PMP .
BRITISH JOURNAL OF HAEMATOLOGY, 1999, 104 (01) :178-185
[34]  
LINDEN HL, IN PRESS BIOCHEMISTR
[35]   Ex vivo expansion of enriched CD34+ cells from neonatal blood in the presence of thrombopoietin, a comparison with cord blood and bone marrow [J].
Liu, J ;
Li, K ;
Yuen, PMP ;
Fok, TF ;
Yau, FW ;
Yang, M ;
Li, CK .
BONE MARROW TRANSPLANTATION, 1999, 24 (03) :247-252
[36]   CLONING AND EXPRESSION OF MURINE THROMBOPOIETIN CDNA AND STIMULATION OF PLATELET PRODUCTION IN-VIVO [J].
LOK, S ;
KAUSHANSKY, K ;
HOLLY, RD ;
KUIJPER, JL ;
LOFTONDAY, CE ;
OORT, PJ ;
GRANT, FJ ;
HEIPEL, MD ;
BURKHEAD, SK ;
KRAMER, JM ;
BELL, LA ;
SPRECHER, CA ;
BLUMBERG, H ;
JOHNSON, R ;
PRUNKARD, D ;
CHING, AFT ;
MATHEWES, SL ;
BAILEY, MC ;
FORSTROM, JW ;
BUDDLE, MM ;
OSBORN, SG ;
EVANS, SJ ;
SHEPPARD, PO ;
PRESNELL, SR ;
OHARA, PJ ;
HAGEN, FS ;
ROTH, GJ ;
FOSTER, DC .
NATURE, 1994, 369 (6481) :565-568
[37]  
Long M W, 1999, Curr Opin Hematol, V6, P159, DOI 10.1097/00062752-199905000-00006
[38]   Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells [J].
Melemed, AS ;
Ryder, JW ;
Vik, TA .
BLOOD, 1997, 90 (09) :3462-3470
[39]  
METHIA N, 1993, BLOOD, V82, P1395
[40]   A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development [J].
Miller, CP ;
Liu, ZY ;
Noguchi, CT ;
Wojchowski, DM .
BLOOD, 1999, 94 (10) :3381-3387