Enantioselective Morita-Baylis-Hillman (MBH) reaction promoted by a heterobimetallic complex with a Lewis base

被引：34

作者：

Matsui, K ^{[1
]}

Takizawa, S ^{[1
]}

Sasai, H ^{[1
]}

机构：

[1] Osaka Univ, ISIR, Osaka 5670047, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期

关键词：

double-activation; Morita-Baylis-Hillman (MBH) reaction;

D O I：

10.1016/j.tetlet.2004.11.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new double-activation catalysis is presented for the Morita-Baylis-Hillman (MBH) reaction of an alpha,beta-unsaturated ketone and an aldehyde by the combined use of a heterobimetallic asymmetric complex and tributylphosphine ((n-Bu)(3)P) to afford the alpha-methylene-beta-hydroxy ketone with up to 99% ce. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：1943 / 1946

页数：4

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