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Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis

被引：100
作者：
Huang, RL
Chen, CC
Huang, HL
Chang, CG
Chen, CF
Chang, CM
Hsieh, MT
机构：
[1] Natl Res Inst Chinese Med, Dept Pharmacol, Taipei 11221, Taiwan
[2] Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei, Taiwan
[3] China Med Coll, Dept Chinese Med, Taichung, Taiwan
来源：
PLANTA MEDICA | 2000年 / 66卷 / 08期
关键词：
human hepatitis B virus; HBsAg; HBeAg; endogenous polymerase activity; Scutellaria baicalensis; Labiatae; wogonin; baicalein; baicalin;
D O I：
10.1055/s-2000-9775
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production (P < 0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.
引用
收藏
页码：694 / 698
页数：5
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