Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root

被引：31

作者：

Liao, JF

Wang, HH

Chen, MC

Chen, CC

Chen, CF

机构：

[1] Natl Res Inst Chinese Med, Taipei 11221, Taiwan

[2] Natl Yang Ming Univ, Dept Pharmacol, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

来源：

PLANTA MEDICA | 1998年 / 64卷 / 06期

关键词：

D O I：

10.1055/s-2006-957517

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellario baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABA(A) receptors with a K-i value of 13.1, 14.6 and 0.36 mu mol/L, respectively.

引用

页码：571 / 572

页数：2

共 8 条

[1]

[Anonymous], 1992, CHINESE DRUGS PLANT

[2]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[3] CORRELATIONS AMONG MINIMAL NEUROTOXICITY, ANTI-CONVULSANT ACTIVITY, AND DISPLACING POTENCIES IN [FLUNITRAZEPAM-H-3 BINDING OF BENZODIAZEPINES [J].