Factor VIII immunogenicity

被引：45

作者：

Jacquemin, MG ^{[1
]}

Saint-Remy, JMR ^{[1
]}

机构：

[1] Catholic Univ Louvain, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium

来源：

HAEMOPHILIA | 1998年 / 4卷 / 04期

关键词：

inhibitors; tolerance; haemophilia; T cell; B cell;

D O I：

10.1046/j.1365-2516.1998.440552.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The immunogenicity of factor VIII depends on the interaction of multiple parametres including host susceptibility and characteristics of the factor VIII preparations. We briefly review here the basic mechanisms by which tolerance to self is established, maintained, and possibly broken in the context of haemophilia A, with special emphasis on the severity of the disease. Reference is also made to the situation observed in healthy individuals and patients with autoantibodies to factor VIII.

引用

页码：552 / 557

页数：6

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