Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

被引：695

作者：

Watson, AA

Fleet, GWJ

Asano, N

Molyneux, RJ

Nash, RJ

机构：

[1] Inst Grassland & Environm Res, Aberystwyth SY23 3EB, Dyfed, Wales

[2] MolecularNat Ltd, Aberystwyth SY23 3EB, Dyfed, Wales

[3] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[4] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan

[5] USDA ARS, Western Reg Res Ctr, Albany, CA 94710 USA

来源：

PHYTOCHEMISTRY | 2001年 / 56卷 / 03期

关键词：

glycosidase; inhibitors; pyrrolidines; piperidines; pyrrolizidines; indolizidines; Nortropanes; N-containing sugars;

D O I：

10.1016/S0031-9422(00)00451-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：265 / 295

页数：31

共 230 条

[81] Synergistic interaction between castanospermine and tacrolimus in a rat heart allograft model [J].