From stem cells to neural networks: recent advances and perspectives for neurodevelopmental disorders

被引：54

作者：

Gaspard, Nicolas ^{[1
]}

Vanderhaeghen, Pierre ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Inst Interdisciplinary Res, B-1070 Brussels, Belgium

来源：

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | 2011年 / 53卷 / 01期

关键词：

WILLIAMS-BEUREN-SYNDROME; MOTOR-NEURONS; DIRECTED DIFFERENTIATION; REPROGRAMMING FACTORS; PARKINSONS-DISEASE; CORTICAL-NEURONS; DEFINED FACTORS; GENERATION; FIBROBLASTS; PLURIPOTENCY;

D O I：

10.1111/j.1469-8749.2010.03827.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Embryonic or induced pluripotent stem cells, available in mouse and human, have emerged as powerful tools to address complex questions in neurobiology. This review focuses on major advances relating to brain development and developmental disorders. Stem cells can differentiate into many different neuronal subtypes using in vitro models mimicking relevant in vivo developmental processes, and the underlying molecular and cellular mechanisms. Disease-specific human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells are now available and allow for the study in vitro of the pathophysiology of degenerative and neurodevelopmental hereditary and sporadic disorders, including in the near future those of the human cortex. Finally, some recent studies have shown that stem cell-derived neural progenitors and neurons could help to rebuild damaged brain circuitry, opening the possibility of cell therapy.

引用

页码：13 / 17

页数：5

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