Incorporation of serinol derived acyclic nucleoside analogues into oligonucleotides: Influence on duplex and triplex formation

被引:29
作者
Benhida, R
Devys, M
Fourrey, JL [1 ]
Lecubin, F
Sun, JS
机构
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
[2] Museum Natl Hist Nat, Biophys Lab, F-75231 Paris 05, France
关键词
D O I
10.1016/S0040-4039(98)01268-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Phosphoramidites 6a-c were readily prepared by an original route and used to incorporate serinol derived units I-III in oligonucleotides which, compared to their natural analogues, exhibited a decreased hybridization capacity for duplex and tripler formation. (C) 1998 Elsevier Science Lid. All rights reserved.
引用
收藏
页码:6167 / 6170
页数:4
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