Incorporation of serinol derived acyclic nucleoside analogues into oligonucleotides: Influence on duplex and triplex formation

被引：29

作者：

Benhida, R

Devys, M

Fourrey, JL ^{[1
]}

Lecubin, F

Sun, JS

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Museum Natl Hist Nat, Biophys Lab, F-75231 Paris 05, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(98)01268-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphoramidites 6a-c were readily prepared by an original route and used to incorporate serinol derived units I-III in oligonucleotides which, compared to their natural analogues, exhibited a decreased hybridization capacity for duplex and tripler formation. (C) 1998 Elsevier Science Lid. All rights reserved.

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页码：6167 / 6170

页数：4

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