Dystroglycan in development and disease

被引：125

作者：

Durbeej, M

Henry, MD

Campbell, KP

机构：

[1] Univ Iowa, Coll Med, Dept Physiol & Biophys, Howard Hughes Med Inst, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Dept Neurol, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(98)80034-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our understanding of the structure and function of dystroglycan, a cell surface laminin/agrin receptor, has increased dramatically over the past two years. Structural studies, analysis of its binding partners, and targeted gene disruption have all contributed to the elucidation of the biological role of dystroglycan in development and disease. It is now apparent that dystroglycan plays a critical role in the pathogenesis of several muscular dystrophies and serves as a receptor for a human pathogen as well as being involved in early development, organ morphogenesis, and synaptogenesis.

引用

收藏

页码：594 / 601

页数：8

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