Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin

被引:35
作者
Briatore, L [1 ]
Andraghetti, G [1 ]
Cordera, R [1 ]
机构
[1] Univ Genoa, Dept Endocrinol & Metab, I-16132 Genoa, Italy
关键词
D O I
10.1530/eje.0.1490403
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The independent role of glucose and insulin in ghrelin regulation is still controversial; this is also because in healthy subjects it is difficult to isolate the increase of glucose from that of insulin. The aim of this study was to discriminate the effect of glucose increase alone and early insulin response on plasma ghrelin, comparing ghrelin variation after i.v. glucose between healthy subjects and type 2 diabetic (T2DM) subjects, in whom the early insulin response to i.v. glucose is abolished. Methods: Plasma glucose, insulin and ghrelin levels were measured 0, 3, 5, 10, 30, 45 and 60 min after a 5 g glucose i.v. bolus in seven healthy control subjects and eight T2DM subjects. Results: There were no significant differences in body mass index, basal insulin and basal ghrelin between T2DM and healthy subjects. Basal glucose levels were higher in T2DM subjects than in controls. After i.v. glucose administration, plasma glucose increased significantly in both groups and the glucose peak was higher in T2DM subjects than in controls (9.67+/-1.25 (S.D.) vs 6.88+/-1.00 mmol/l, P < 0.01). Insulin increased rapidly in controls, while in T2DM subjects, plasma insulin did not rise in the first 10 min. After the glucose bolus, plasma ghrelin showed a significant reduction both in controls and in T2DM subjects after 5 min. Conclusion: These findings indicate that a low-dose i.v. glucose bolus reduces ghrelin both in controls and in T2DM subjects and therefore that early insulin response does not affect plasma ghrelin.
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页码:403 / 406
页数:4
相关论文
共 15 条
[1]   Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans [J].
Arvat, E ;
Di Vito, L ;
Broglio, F ;
Papotti, M ;
Muccioli, G ;
Dieguez, C ;
Casanueva, FF ;
Deghenghi, R ;
Camanni, F ;
Ghigo, E .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (08) :493-495
[2]   Insulin, unlike food intake, does not suppress ghrelin in human subjects. [J].
Caixás, A ;
Bashore, C ;
Nash, W ;
Pi-Sunyer, FX ;
Laferrère, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (04) :1902-1906
[3]   Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients [J].
Cappiello, V ;
Ronchi, C ;
Morpurgo, PS ;
Epaminonda, P ;
Arosio, M ;
Beck-Peccoz, P ;
Spada, A .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 147 (02) :189-194
[4]   A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans [J].
Cummings, DE ;
Purnell, JQ ;
Frayo, RS ;
Schmidova, K ;
Wisse, BE ;
Weigle, DS .
DIABETES, 2001, 50 (08) :1714-1719
[5]   The influence of insulin on circulating ghrelin [J].
Flanagan, DE ;
Evans, ML ;
Monsod, TP ;
Rife, F ;
Heptulla, RA ;
Tamborlane, WV ;
Sherwin, RS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (02) :E313-E316
[6]   Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].
Kojima, M ;
Hosoda, H ;
Date, Y ;
Nakazato, M ;
Matsuo, H ;
Kangawa, K .
NATURE, 1999, 402 (6762) :656-660
[7]   Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia [J].
Lucidi, P ;
Murdolo, G ;
Di Loreto, C ;
De Cicco, A ;
Parlanti, N ;
Fanelli, C ;
Santeusanio, F ;
Bolli, GB ;
De Feo, P .
DIABETES, 2002, 51 (10) :2911-2914
[8]  
Möhlig M, 2002, J ENDOCRINOL INVEST, V25, pRC36
[9]   Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose [J].
Nakagawa, E ;
Nagaya, N ;
Okumura, H ;
Enomoto, M ;
Oya, H ;
Ono, F ;
Hosoda, H ;
Kojima, M ;
Kangawa, K .
CLINICAL SCIENCE, 2002, 103 (03) :325-328
[10]   Section 2: Biphasic insulin release: Pools and signal modulation - Modeling phasic insulin release - Immediate and time-dependent effects of glucose [J].
Nesher, R ;
Cerasi, E .
DIABETES, 2002, 51 :S53-S59