Palladium-catalyzed carbonylation of haloindoles:: No need for protecting groups

被引：73

作者：

Kumar, K

Zapf, A

Michalik, D

Tillack, A

Heinrich, T

Böttcher, H

Arlt, M

Beller, M

机构：

[1] Univ Rostock, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] E Merck AG, D-64293 Darmstadt, Germany

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1021/ol035988r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the first time, palladium-catalyzed carbonylations of unprotected bromoindoles have been performed successfully with different N- and O-nucleophiles. Various indole carboxylic acid derivatives are accessible in excellent yield. For example, aminocarbonylation of 4-, 5-, 6-, or 7-bromoindole with arylethylpiperazines provides a direct one-step synthesis for CNS active amphetamine derivatives.

引用

页码：7 / 10

页数：4

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