Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light

被引：14

作者：

Guerrero, JM ^{[1
]}

Pablos, MI ^{[1
]}

Ortiz, GG ^{[1
]}

Agapito, MT ^{[1
]}

Reiter, RJ ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284

来源：

NEUROCHEMISTRY INTERNATIONAL | 1996年 / 29卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/0197-0186(95)00162-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diurnal variations in the contents of nitric oxide (NO) and cyclic GMP were studied in the chick brain. NO and cyclic GMP contents in the chick brain were lower at night than during the day and were inversely correlated with high night-time tissue melatonin levels. Furthermore, when animals were kept in light at night, tissue melatonin levels remained at low diurnal values, whereas NO and cyclic GMP contents remained high. Since we have previously shown that physiological concentrations of melatonin inhibit nitric oxide synthase (NOS) activity in different brain areas,he nocturnal decrease in brain NO and cyclic GMP contents may be, in part, a consequence of the nocturnal inhibitory effect of melatonin on NOS activity. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：417 / 421

页数：5

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