Aspects of immune dysfunction in end-stage renal disease

被引：803

作者：

Kato, Sawako ^{[1
,2
,3
]}

Chmielewski, Michal ^{[1
,2
,4
]}

Honda, Hirokazu ^{[5
]}

Pecoits-Filho, Roberto ^{[6
]}

Matsuo, Seiichi ^{[3
]}

Yuzawa, Yukio ^{[3
]}

Tranaeus, Anders ^{[1
,2
]}

Stenvinkel, Peter ^{[1
,2
]}

Lindholm, Bengt ^{[1
,2
]}

机构：

[1] K 56 Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden

[2] K 56 Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, S-14186 Huddinge, Sweden

[3] Nagoya Univ, Grad Sch Med, Div Clin Immunol, Dept Internal Med, Nagoya, Aichi 4648601, Japan

[4] Med Univ Gdansk, Dept Nephrol Transplant & Internal Med, Gdansk, Poland

[5] Showa Univ, Sch Med, Dept Nephrol, Tokyo 142, Japan

[6] Pontificia Univ Catolica Parana, Ctr Ciencias Biol & Saude, Curitiba, Parana, Brazil

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 3卷 / 05期

关键词：

D O I：

10.2215/CJN.00950208

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

End-stage renal disease (ESRD) is associated with significantly increased morbidity and mortality resulting from cardiovascular disease (CVD) and infections, accounting for 50% and 20%, respectively, of the total mortality in ESRD patients. It is possible that these two complications are linked to alterations in the immune system in ESRD, as uremia is associated with a state of immune dysfunction characterized by immunodepression that contributes to the high prevalence of infections among these patients, as well as by immunoactivation resulting in inflammation that may contribute to CVD. This review describes disorders of the innate and adaptive immune systems in ESRD, underlining the specific role of ESRD-associated disturbances of Toll-like receptors. Finally, based on the emerging links between the alterations of immune system, CVD, and infections in ESRD patients, it emphasizes the potential role of the immune dysfunction in ESRD as an underlying cause for the high mortality in this patient population and the need for more studies in this area.

引用

页码：1526 / 1533

页数：8

共 66 条

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