Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian's patients: An association with histopathological parameters

被引：41

作者：

Lima, Valeska Portela ^{[1
]}

de Lima Silva-Fernandes, Isabelle Joyce ^{[1
]}

Santos Alves, Markenia Kelia ^{[1
]}

Barem Rabenhorst, Silvia Helena ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Patol & Med Legal, Lab Genet Mol LABGEM, BR-60183630 Fortaleza, Ceara, Brazil

来源：

CANCER EPIDEMIOLOGY | 2011年 / 35卷 / 05期

关键词：

Gastric cancer; Helicobacter pylori; cagA; vacA; cagE and virB11; PATHOGENICITY ISLAND; BIOPSY SPECIMENS; EPITHELIAL-CELLS; CLINICAL-RELEVANCE; VIRULENCE FACTORS; BABA2; GENOTYPES; DUODENAL-ULCER; ADULT PATIENTS; PEPTIC-ULCER; TOXIN VACA;

D O I：

10.1016/j.canep.2011.02.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: To investigate the frequency and the association of vacA alleles, cagA, cagE and virB11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods: One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vacA alleles, cagA, cagE and virB11. Results: The distribution of cases according to the presence of the genes studied showed that the group containing vacA s1m1, cagA, cagE and virB11 H. pylori genes was significantly more frequent, followed by the group with at least one marker on the right side and left of the island. They were also present in the early stages and were the most frequent in nearly all histopathological grades. Conclusions: This study verified that vacAs1m1 and cog-PAI genes, cagA, cagE and virB11 are important H. pylori markers for gastric cancer development. Also, this study corroborates the importance of cagE and cagA together as cog-PAI marker. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：E32 / E37

页数：6

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