Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma

被引：60

作者：

Ashour, AAR

Magalhaes, PP

Mendes, EN

Collares, GB

de Gusmao, VR

Queiroz, DMM

Nogueira, AMMF

Rocha, GA

de Oliveira, CA

机构：

[1] Univ Fed Minas Gerais, Mol Biol Lab, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Lab Res Bacteriol, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Pathol, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil

[4] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol, BR-04023062 Sao Paulo, Brazil

[5] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, BR-21941590 Rio De Janeiro, Brazil

[6] Univ Itauna, Fac Fisioterapia, BR-35680033 Itauna, Brazil

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2002年 / 33卷 / 03期

关键词：

vacA; cagA; bacterial genetic diversity; Helicobacter pylori;

D O I：

10.1111/j.1574-695X.2002.tb00588.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution in adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified in 11/13.4% patients. vacA sl-ml and cagA(+) genotypes were the most common in patients with a non-mixed infection. All vacA s1 strains were s1b, so subtyping s1 strains was not useful. vacA s1b-m1 and cagA(+) strains were associated with higher prevalence of peptic ulcer and gastric carcinoma than vacA s2-m2 and cagA(-) ones. In conclusion, cagA and vacA genotyping may have clinical relevance in Brazil. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：173 / 178

页数：6

共 34 条

[1] Recombination and clonal groupings within Helicobacter pylori from different geographical regions [J].