Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity

被引:23
作者
Clader, JW [1 ]
Billard, W [1 ]
Binch, H [1 ]
Chen, LY [1 ]
Crosby, G [1 ]
Duffy, RA [1 ]
Ford, J [1 ]
Kozlowski, JA [1 ]
Lachowicz, JE [1 ]
Li, SJ [1 ]
Liu, C [1 ]
McCombie, SW [1 ]
Vice, S [1 ]
Zhou, GW [1 ]
Greenlee, WJ [1 ]
机构
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
10.1016/j.bmc.2003.11.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:319 / 326
页数:8
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