Total synthesis of natural (+)-FR900482 .1. Synthetic and end-game strategies

被引：37

作者：

Katoh, T ^{[1
]}

Itoh, E ^{[1
]}

Yoshino, T ^{[1
]}

Terashima, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期

关键词：

D O I：

10.1016/0040-4039(96)00593-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic strategy for natural (+)-FR900482 (1) war developed by featuring a convergent and enantioselective sequence which commences with S-hydroxyisophthalic acid and L-diethyl tartrate. The proposed key intermediate 4 was synthesized starting from FK973, the triacetyl derivative of 1, and successful reconversion of 4 into 1 was also achieved. These preliminary studies definitely demonstrated that 4 is suitable as a potential relay compound toward 1 and that the crucial final sequence of reactions (4-->1) involving delicate deprotection and oxidation steps can be realized. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3471 / 3474

页数：4

共 29 条

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