Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function

被引:490
作者
Stetson, DB
Mohrs, M
Reinhardt, RL
Baron, JL
Wang, ZE
Gapin, L
Kronenberg, M
Locksley, RM
机构
[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Immunol Microbiol, San Francisco, CA 94143 USA
[3] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA
关键词
NK T cells; NK cells; cytokine mRNAs; IL-4; IFN-gamma;
D O I
10.1084/jem.20030630
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-gamma transcription during thymic development and populate the periphery with both cytokine loci previously modified by historic acetylation. Similarly, NK cells transcribe and modify the IFN-gamma gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes.
引用
收藏
页码:1069 / 1076
页数:8
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