Two new constituents of Isodon excisus and their evaluation in an apoptosis inhibition assay

被引：46

作者：

Lee, C ^{[1
]}

Kim, J ^{[1
]}

Lee, H ^{[1
]}

Lee, S ^{[1
]}

Kho, Y ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 05期

关键词：

D O I：

10.1021/np000604g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of the whole plant of Isodon excisus resulted in the isolation of two new apoptosis inhibitors (1 and 2). Compounds 1 and 2 inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 10.2 and 52.4 mug/mL, respectively. The structures of 1 and 2 were determined by spectral data interpretation.

引用

页码：659 / 660

页数：2

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