Spotting the target: microarrays for disease gene discovery

被引:41
作者
Meltzer, PS [1 ]
机构
[1] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0959-437X(00)00187-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Microarray technologies enable genome-scale expression measurements. Already proved to be of value for the functional analysis of individual genes and biological processes, the application of expression profiling to disease gene discovery is now growing in importance and practicality.
引用
收藏
页码:258 / 263
页数:6
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[1]   Algorithms for identifying Boolean networks and related biological networks based on matrix multiplication and fingerprint function [J].
Akutsu, T ;
Miyano, S ;
Kuhara, S .
JOURNAL OF COMPUTATIONAL BIOLOGY, 2000, 7 (3-4) :331-343
[2]   Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].
Alizadeh, AA ;
Eisen, MB ;
Davis, RE ;
Ma, C ;
Lossos, IS ;
Rosenwald, A ;
Boldrick, JG ;
Sabet, H ;
Tran, T ;
Yu, X ;
Powell, JI ;
Yang, LM ;
Marti, GE ;
Moore, T ;
Hudson, J ;
Lu, LS ;
Lewis, DB ;
Tibshirani, R ;
Sherlock, G ;
Chan, WC ;
Greiner, TC ;
Weisenburger, DD ;
Armitage, JO ;
Warnke, R ;
Levy, R ;
Wilson, W ;
Grever, MR ;
Byrd, JC ;
Botstein, D ;
Brown, PO ;
Staudt, LM .
NATURE, 2000, 403 (6769) :503-511
[3]  
Amler LC, 2000, CANCER RES, V60, P6134
[4]   Gene Ontology: tool for the unification of biology [J].
Ashburner, M ;
Ball, CA ;
Blake, JA ;
Botstein, D ;
Butler, H ;
Cherry, JM ;
Davis, AP ;
Dolinski, K ;
Dwight, SS ;
Eppig, JT ;
Harris, MA ;
Hill, DP ;
Issel-Tarver, L ;
Kasarskis, A ;
Lewis, S ;
Matese, JC ;
Richardson, JE ;
Ringwald, M ;
Rubin, GM ;
Sherlock, G .
NATURE GENETICS, 2000, 25 (01) :25-29
[5]  
Bärlund M, 2000, CANCER RES, V60, P5340
[6]   A compound heterozygous one amino-acid insertion/nonsense mutation in the plectin gene causes epidermolysis bullosa simplex with plectin deficiency [J].
Bauer, JW ;
Rouan, F ;
Kofler, B ;
Rezniczek, GA ;
Kornacker, I ;
Muss, W ;
Hametner, R ;
Klausegger, A ;
Huber, A ;
Pohla-Gubo, G ;
Wiche, G ;
Uitto, J ;
Hintner, H .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (02) :617-625
[7]   Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].
Bittner, M ;
Meitzer, P ;
Chen, Y ;
Jiang, Y ;
Seftor, E ;
Hendrix, M ;
Radmacher, M ;
Simon, R ;
Yakhini, Z ;
Ben-Dor, A ;
Sampas, N ;
Dougherty, E ;
Wang, E ;
Marincola, F ;
Gooden, C ;
Lueders, J ;
Glatfelter, A ;
Pollock, P ;
Carpten, J ;
Gillanders, E ;
Leja, D ;
Dietrich, K ;
Beaudry, C ;
Berens, M ;
Alberts, D ;
Sondak, V ;
Hayward, N ;
Trent, J .
NATURE, 2000, 406 (6795) :536-540
[8]   Knowledge-based analysis of microarray gene expression data by using support vector machines [J].
Brown, MPS ;
Grundy, WN ;
Lin, D ;
Cristianini, N ;
Sugnet, CW ;
Furey, TS ;
Ares, M ;
Haussler, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) :262-267
[9]   High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH [J].
Bruder, CEG ;
Hirvelä, C ;
Tapia-Paez, I ;
Fransson, I ;
Segraves, R ;
Hamilton, G ;
Zhang, XX ;
Evans, DG ;
Wallace, AJ ;
Baser, ME ;
Zucman-Rossi, J ;
Hergersberg, M ;
Boltshauser, E ;
Papi, L ;
Rouleau, GA ;
Poptodorov, G ;
Jordanova, A ;
Rask-Andersen, H ;
Kluwe, L ;
Mautner, V ;
Sainio, M ;
Hung, G ;
Mathiesen, T ;
Möller, C ;
Pulst, SM ;
Harder, H ;
Heiberg, A ;
Honda, M ;
Miimura, M ;
Sahlén, S ;
Blennow, E ;
Albertson, DG ;
Pinkel, D ;
Dumanski, JP .
HUMAN MOLECULAR GENETICS, 2001, 10 (03) :271-282
[10]   Microarray expression profiling identifies genes with altered expression in HDL-deficient mice [J].
Callow, MJ ;
Dudoit, S ;
Gong, EL ;
Speed, TP ;
Rubin, EM .
GENOME RESEARCH, 2000, 10 (12) :2022-2029