Cortactin in tumor invasiveness

被引：181

作者：

Weaver, Alissa M. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA

来源：

CANCER LETTERS | 2008年 / 265卷 / 02期

关键词：

cortactin; tumor; invasion; migration; invadopodia;

D O I：

10.1016/j.canlet.2008.02.066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed in cancer. Animal studies suggest that cortactin overexpression increases tumor aggressiveness, possibly through promotion of tumor invasion and metastasis. Recently, many studies have documented a role for cortactin in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the extracellular matrix by cancer cells. Here, I review the evidence and potential mechanisms for cortactin as a critical mediator of tumor cell invasion. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：157 / 166

页数：10

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