Does it take two to untangle?

被引:1
作者
Bertsch, DN [1 ]
Lindsley, JE [1 ]
机构
[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA
关键词
D O I
10.1016/S0092-8674(03)00763-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structural integrity of mitotic chromosomes is essential for proper chromatid segregation. In this issue of Cell, Ono et al. (2003) show that vertebrates contain two distinct condensin complexes, both of which are required for normal mitotic chromosome morphology.
引用
收藏
页码:4 / 6
页数:3
相关论文
共 10 条
[1]   C-elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis [J].
Hagstrom, KA ;
Holmes, VF ;
Cozzarelli, NR ;
Meyer, BJ .
GENES & DEVELOPMENT, 2002, 16 (06) :729-742
[2]   Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein [J].
Hirano, T ;
Kobayashi, R ;
Hirano, M .
CELL, 1997, 89 (04) :511-521
[3]   Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes [J].
Hudson, DF ;
Vagnarelli, P ;
Gassmann, R ;
Earnshaw, WC .
DEVELOPMENTAL CELL, 2003, 5 (02) :323-336
[4]   The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous chromosomes during meiosis [J].
Kaitna, S ;
Pasierbek, P ;
Jantsch, M ;
Loidl, J ;
Glotzer, M .
CURRENT BIOLOGY, 2002, 12 (10) :798-812
[5]   Distinct cohesin complexes organize meiotic chromosome domains [J].
Kitajima, TS ;
Yokobayashi, S ;
Yamamoto, M ;
Watanabe, Y .
SCIENCE, 2003, 300 (5622) :1152-1155
[6]   A two-step scaffolding model for mitotic chromosome assembly [J].
Maeshima, K ;
Laemmli, UK .
DEVELOPMENTAL CELL, 2003, 4 (04) :467-480
[7]   Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells [J].
Ono, T ;
Losada, A ;
Hirano, M ;
Myers, MP ;
Neuwald, AF ;
Hirano, T .
CELL, 2003, 115 (01) :109-121
[8]   Kleisins: A superfamily of bacterial and eukaryotic SMC protein partners [J].
Schleiffer, A ;
Kaitna, S ;
Maurer-Stroh, S ;
Glotzer, M ;
Nasmyth, K ;
Eisenhaber, F .
MOLECULAR CELL, 2003, 11 (03) :571-575
[9]   A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis [J].
Steffensen, S ;
Coelho, PA ;
Cobbe, N ;
Vass, S ;
Costa, M ;
Hassan, B ;
Prokopenko, SN ;
Bellen, H ;
Heck, MMS ;
Sunkel, CE .
CURRENT BIOLOGY, 2001, 11 (05) :295-307
[10]   SMC2, A SACCHAROMYCES-CEREVISIAE GENE ESSENTIAL FOR CHROMOSOME SEGREGATION AND CONDENSATION, DEFINES A SUBGROUP WITHIN THE SMC FAMILY [J].
STRUNNIKOV, AV ;
HOGAN, E ;
KOSHLAND, D .
GENES & DEVELOPMENT, 1995, 9 (05) :587-599