Transgenes as screening tools to probe and manipulate the zebrafish genome

被引：39

作者：

Amsterdam, A

Becker, TS

机构：

[1] MIT, Canc Res Ctr, Cambridge, MA USA

[2] Univ Bergen, Sars Int Ctr Marine Mol Biol, Bergen, Norway

来源：

DEVELOPMENTAL DYNAMICS | 2005年 / 234卷 / 02期

关键词：

insertional mutagenesis; gene-trap; enhancer; retrovirus; transposon; functional genomics;

D O I：

10.1002/dvdy.20541

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The zebrafish, originally an object of study as an inexpensive and prolific vertebrate embryological model with a plethora of genetic tricks, has over the past decade moved to large-scale chemical mutagenesis and recently came of age as a high throughput transgenic model with a sequenced genome nearing completion. Insertional mutagenesis, gene trapping and enhancer detection are all contributing to the increasing speed with which research in this biomedical model is progressing. We review here some of the recent developments in the emerging field of zebrafish developmental genomics and transgenesis.

引用

收藏

页码：255 / 268

页数：14

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