Formulation Strategies of Nano Lipid Carrier for Effective Brain Targeting of Anti-AD Drugs

被引：8

作者：

Alexander, Amit ^{[1
]}

Agrawal, Mukta ^{[2
]}

Saraf, Swarnlata ^{[3
]}

Saraf, Shailendra ^{[3
]}

Ajazuddin ^{[2
]}

Chougule, Mahavir B. ^{[4
,5
,6
]}

机构：

[1] Govt India, Natl Inst Pharmaceut Educ & Res NIPER Guwahati, Dept Pharmaceut, Minist Chem & Fertilizers,NITS Mirza, NH 37, Gauhati 781125, Assam, India

[2] Rungta Coll Pharmaceut Sci & Res, Kohka Kurud Rd, Chhattisgarh 490024, India

[3] Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, Chhattisgarh, India

[4] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Dept Pharmaceut & Drug Delivery,Translat Biopharm, University, MS 38677 USA

[5] Univ Mississippi, Pii Ctr Pharmaceut Technol, Res Inst Pharmaceut Sci, University, MS 38677 USA

[6] Univ Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2020年 / 26卷 / 27期

关键词：

Nanostructured lipid carrier; lipid; brain; BBB; Alzheimer's disease; fabrication techniques; FIELD-FLOW FRACTIONATION; SOLVENT DIFFUSION METHOD; NANOPARTICLES SLN; DELIVERY-SYSTEM; ELECTRON-MICROSCOPY; NLC; CURCUMIN; DESIGN; BIODISTRIBUTION; OPTIMIZATION;

D O I：

10.2174/1381612826666200212120947

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

NLC is a next-generation lipid nanocarrier, which holds many advantages over other colloidal lipid carrier systems like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend, it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can easily be modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications for the treatment of various CNS disorders including Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, migraine, cerebral ischemia, etc. Among these, the application of NLC towards the treatment of AD has been well-explored in the past two decades. in this piece of work, we have discussed the types of NLC, its composition, fabrication techniques, characterization, stability profile and application in the treatment of AD.

引用

页码：3269 / 3280

页数：12

共 84 条

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