Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin

被引：14

作者：

Pérez-Guerrero, C ^{[1
]}

Márquez-Martín, A ^{[1
]}

Herrera, MD ^{[1
]}

Marhuenda, E ^{[1
]}

de Sotomayor, MA ^{[1
]}

机构：

[1] Univ Seville, Fac Pharm, Dept Pharmacol, ES-41012 Seville, Spain

来源：

PHARMACOLOGY | 2005年 / 74卷 / 04期

关键词：

HMG-CoA reductase; simvastatin; calcium; Rho-kinase; spontaneously hypertensive rat;

D O I：

10.1159/000085957

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The acute effect of simvastatin on aortic rings from spontaneously hypertensive rats (SHRs) was identified. Simvastatin-evoked relaxations of both depolarized and phenylephrine-precontracted arteries were independent of the presence of endothelium. This effect was inhibited by diltiazem and mevalonate, but not by the Rho-kinase inhibitor, Y-27632. Simvastatin prevented contraction induced by phenylephrine, calcium ionophore A-23187 and CaCl2 in Ca2+- free medium. Y-27632 decreased the effect of simvastatin. On the contrary, contraction induced by noradrenaline in Ca2+- free medium was not affected. These results suggest that simvastatin elicited an effect on vascular smooth muscle cells from SHRs that may involve blockade of extracellular calcium entry and decrease vascular contraction by affecting Rho-kinase. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：209 / 215

页数：7

共 26 条

[11]

HIRATA K, 1992, J BIOL CHEM, V267, P8719

[12] Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations [J].

Kantola, T ;

Kivistö, KT ;

Neuvonen, PJ .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 64 (02) :177-182

[13] Neuroprotection mediated by changes in the endothelial actin cytoskeleton [J].

Laufs, U ;

Endres, M ;

Stagliano, N ;

Amin-Hanjani, S ;

Chui, DS ;

Yang, SX ;

Simoncini, T ;

Yamada, M ;

Rabkin, E ;

Allen, PG ;

Huang, PL ;

Böhm, M ;

Schoen, FJ ;

Moskowitz, MA ;

Liao, JK .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (01) :15-24

[14] Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors [J].

Laufs, U ;

La Fata, V ;

Plutzky, J ;

Liao, JK .

CIRCULATION, 1998, 97 (12) :1129-1135

[15] Grapefruit juice-simvastatin interaction:: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors [J].

Lilja, JJ ;

Kivistö, KT ;

Neuvonen, PJ .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 64 (05) :477-483

[16] 3-HYDROXY-3-METHYL GLUTARYL COENZYME-A REDUCTASE INHIBITION MODULATES VASOPRESSIN-STIMULATED CA2+ RESPONSES IN RAT A10 VASCULAR SMOOTH-MUSCLE CELLS [J].

NG, LL ;

DAVIES, JE ;

WOJCIKIEWICZ, RJH .

CIRCULATION RESEARCH, 1994, 74 (02) :173-181

[17] Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month [J].

ODriscoll, G ;

Green, D ;

Taylor, RR .

CIRCULATION, 1997, 95 (05) :1126-1131

[18]

PEDERSEN TR, 1994, LANCET, V344, P1383

[19]

Rahmani Munir A., 1999, Frontiers in Bioscience, V4, pD408, DOI 10.2741/Rahmani

[20]

Raiteri M, 1997, J PHARMACOL EXP THER, V281, P1144

← 1 2 3 →