Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin

被引：62

作者：

Andreini, Manuel ^{[2
,3
]}

Doknic, Daniela ^{[2
,3
]}

Sutkeviciute, Ieva ^{[1
,6
]}

Reina, Jose J. ^{[2
,3
]}

Duan, Janxin ^{[4
]}

Chabrol, Eric ^{[1
,6
]}

Thepaut, Michel ^{[1
,6
,7
]}

Moroni, Elisabetta ^{[2
,3
]}

Doro, Fabio ^{[2
,3
]}

Belvisi, Laura ^{[2
,3
]}

Weiser, Joerg ^{[4
]}

Rojo, Javier ^{[5
]}

Fieschi, Franck ^{[1
,6
,8
]}

Bernardi, Anna ^{[2
,3
]}

机构：

[1] Univ Grenoble 1, Inst Biol Struct, F-38027 Grenoble, France

[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[3] CISI, I-20133 Milan, Italy

[4] Anterio Consult & Res, D-68165 Mannheim, Germany

[5] Univ Seville, CSIC, Glycosyst Lab, Inst Invest Quim, Seville 41092, Spain

[6] CNRS, UMR 5075, Grenoble, France

[7] CEA, Grenoble, France

[8] Inst Univ France, F-75005 Paris, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 16期

关键词：

C-TYPE LECTINS; DENDRITIC CELLS; STRUCTURAL BASIS; TRANS-INFECTION; HIV-1; TRANSMISSION; EBOLA-VIRUS; T-CELLS; BINDING; RECOGNITION; RECEPTORS;

D O I：

10.1039/c1ob05573a

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le(X)). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.

引用

页码：5778 / 5786

页数：9

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[1]

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans [J].