Phospholipase D: a lipid centric review

被引：385

作者：

Jenkins, GM

Frohman, MA

机构：

[1] SUNY Stony Brook, Dept Pharmacol, Med Ctr, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Ctr Dev Genet, Med Ctr, Stony Brook, NY 11794 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 19-20期

关键词：

phospholipase D; phosphatidic acid; diacylglercol; phosphatidylcholine; signal transduction;

D O I：

10.1007/s00018-005-5195-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the glycerolipid phosphatidylcholine, resulting in the production of phosphatidic acid and free choline. Phosphatidic acid is widely considered to be the intracellular lipid mediator of many of the biological functions attributed to PLD. However, phosphatidic acid is a tightly regulated lipid in cells and can be converted to other potentially bioactive lipids, including diacylglycerol and lysophosphatidic acid. PLD activities have been described in multiple organisms, including plants, mammals, bacteria and yeast. In mammalian systems, PLD activity regulates the actin cytoskeleton, vesicle trafficking for secretion and endocytosis, and receptor signaling. PLD is in turn regulated by phosphatidylinositol-4,5-bisphosphate, protein kinase C and ADP Ribosylation Factor and Rho family GTPases. This review focuses on the lipid precursors and products of mammalian PLD metabolism, especially phosphatidic acid and the roles this lipid performs in the mediation of the functions of PLD.

引用

收藏

页码：2305 / 2316

页数：12

相关论文

共 164 条

[21] Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network [J].

Chen, YG ;

Siddhanta, A ;

Austin, CD ;

Hammond, SM ;

Sung, TC ;

Frohman, MA ;

Morris, AJ ;

Shields, D .

JOURNAL OF CELL BIOLOGY, 1997, 138 (03) :495-504

[22] Alternative phospholipase D/mTOR survival signal in human breast cancer cells [J].

Chen, YH ;

Rodrik, V ;

Foster, DA .

ONCOGENE, 2005, 24 (04) :672-679

[23] Phospholipase D confers rapamycin resistance in human breast cancer cells [J].

Chen, YH ;

Zheng, Y ;

Foster, DA .

ONCOGENE, 2003, 22 (25) :3937-3942

[24] Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases [J].

Choi, WS ;

Chahdi, A ;

Kim, YM ;

Fraundorfer, PF ;

Beaven, MA .

PROTEIN KINASE A AND HUMAN DISEASE, 2002, 968 :198-212

[25] Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells [J].

Choi, WS ;

Kim, YM ;

Combs, C ;

Frohman, MA ;

Beaven, MA .

JOURNAL OF IMMUNOLOGY, 2002, 168 (11) :5682-5689

[26] THE FATTY-ACID COMPOSITION OF PHOSPHATIDYLINOSITOL, PHOSPHATIDATE AND 1,2-DIACYLGLYCEROL IN STIMULATED HUMAN-NEUTROPHILS [J].

COCKCROFT, S ;

ALLAN, D .

BIOCHEMICAL JOURNAL, 1984, 222 (02) :557-559

[27] Cloning and expression analysis of murine phospholipase D1 [J].

Colley, WC ;

Altshuller, YM ;

SueLing, CK ;

Copeland, NG ;

Gilbert, DJ ;

Jenkins, NA ;

Branch, KD ;

Tsirka, SE ;

Bollag, RJ ;

Bollag, WB ;

Frohman, MA .

BIOCHEMICAL JOURNAL, 1997, 326 :745-753

[28] Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization [J].

Colley, WC ;

Sung, TC ;

Roll, R ;

Jenco, J ;

Hammond, SM ;

Altshuller, Y ;

BarSagi, D ;

Morris, AJ ;

Frohman, MA .

CURRENT BIOLOGY, 1997, 7 (03) :191-201

[29] EPIDERMAL GROWTH-FACTOR INCREASES SN-1,2-DIACYLGLYCEROL LEVELS AND ACTIVATES PHOSPHOLIPASE D-CATALYZED PHOSPHATIDYLCHOLINE BREAKDOWN IN SWISS 3T3 CELLS IN THE ABSENCE OF INOSITOL-LIPID HYDROLYSIS [J].

COOK, SJ ;

WAKELAM, MJO .

BIOCHEMICAL JOURNAL, 1992, 285 :247-253

[30] Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells [J].

Cummings, RJ ;

Parinandi, NL ;

Zaiman, A ;

Wang, LX ;

Usatyuk, PV ;

Garcia, JGN ;

Natarajan, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :30227-30235

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