Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex

被引：61

作者：

Belgorodsky, B

Fadeev, L

Ittah, V

Benyamini, H

Zelner, S

Huppert, D

Kotlyar, AB

Gozin, M ^{[1
]}

机构：

[1] Tel Aviv Univ, Fac Exact Sci, Sch Chem, Fac Life Sci, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Fac Life Sci, Dept Biochem, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Fac Life Sci, Bioinformat Unit, IL-69978 Tel Aviv, Israel

[4] Bar Ilan Univ, Sch Chem, Fac Exact Sci, IL-52900 Ramat Gan, Israel

来源：

BIOCONJUGATE CHEMISTRY | 2005年 / 16卷 / 05期

关键词：

D O I：

10.1021/bc050103c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation and characterization of the stable human serum albumin (HSA)-C-3 isomer of trismalonic acid [C-60] fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein -fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.

引用

页码：1058 / 1062

页数：5

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