Synthesis of fipronil sulfide, an active metabolite, from the parent insecticide fipronil

被引：20

作者：

Beeler, AB

Schlenk, DK

Rimoldi, JM ^{[1
]}

机构：

[1] Univ Mississippi, Dept Med Chem, Mississippi State, MS 38677 USA

[2] Univ Mississippi, Res Inst Pharmaceut Sci, Mississippi State, MS 38677 USA

[3] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

关键词：

fipronil; sulfoxide; reduction; sulfide;

D O I：

10.1016/S0040-4039(01)01043-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient procedure for the synthesis of fipronil sulfide, one of several active metabolites identified from the insecticide fipronil, has been developed. Reduction of fipronil with trifluoroacetic anhydride-sodium iodide in acetone, followed by Rash chromatography afforded fipronil sulfide in 60% yield and > 99.9 percent purity. This represents the first direct synthesis of this key metabolite from fipronil. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5371 / 5372

页数：2

共 21 条

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