Aβ generation in autophagic vacuoles

被引：37

作者：

Mizushima, N ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan

[2] Japan Sci & Technol Agcy, Kawaguchi 3320012, Japan

来源：

JOURNAL OF CELL BIOLOGY | 2005年 / 171卷 / 01期

关键词：

D O I：

10.1083/jcb.200508097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of beta-amyloid (A beta) deposits called senile or neuritic plaques. A beta is generated by the proteolytic cleavage of A beta precursor protein (APP) by beta and gamma-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of A beta peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.

引用

页码：15 / 17

页数：3

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