Self-renewal and cancer of the gut: Two sides of a coin

被引：548

作者：

Radtke, F

Clevers, H

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

SCIENCE | 2005年 / 307卷 / 5717期

关键词：

D O I：

10.1126/science.1104815

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control homeostatic self-renewal and those that underlie colorectal cancer are remarkably symmetrical. Here, we discuss the biology of the intestinal epithelium, emphasizing the roles played by Wnt, bone morphogenic protein, and Notch signaling cascades in epithelial self-renewal and cancer.

引用

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页码：1904 / 1909

页数：6

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