Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: Associations with suicidal behavior and its risk factors

被引:42
作者
Pfeffer, CR
McBride, PA
Anderson, GM
Kakuma, T
Fensterheim, L
Khait, V
机构
[1] Cornell Univ, Coll Med, Dept Psychiat, White Plains, NY USA
[2] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA
[3] Cornell Univ, New York Hosp, Med Ctr, Westchester Div, White Plains, NY 10605 USA
[4] New York Hosp, New York, NY 10021 USA
关键词
serotonin measures; prepubertal suicidal behavior;
D O I
10.1016/S0006-3223(98)00020-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: This study reports relationships between suicidal behavior and its risk factors in prepubertal children and whole blood and platelet serotonin-related measures. Methods: Seventy-five prepubertal psychiatric inpatients including 23 (30.7%) nonsuicidal, 32 (42.7%) with suicidal ideation, and 20 (26.6%) with a suicide attempt were compared to 35 normal prepubertal controls with regard to platelet serotonin content serotonin-amplified platelet aggregation, and whole blood tryptophan. Results: Mean whole blood tryptophan content was significantly lower among inpatient children,vith a recent suicide attempt than among normal controls or inpatients,vith suicidal ideation (F = 3.94, df = 3.54, p less than or equal to .01). Inpatient children with a mood disorder had significantly higher platelet serotonin content than inpatients,without a mood disorder (F = 3.86, df = 2,80, p less than or equal to .03), Racial/ethnic differences were also observed for inpatients and normal controls, with whites having significantly lon er levels of platelet serotonin (expressed as ng/mL blood or ng/10(9) platelets) than blacks or Latinos. Blacks had significantly higher levels of whole blood tryptophan than other racial/ethnic groups. Conclusions: The results suggest that whole blood tryptophan and platelet serotonin content should be studied for their predictive validity as risk factors for suicidal behavior in youth while controlling for racial/ethnic differences. (C) 1998 Society of Biological Psychiatry.
引用
收藏
页码:568 / 577
页数:10
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