A mechanism for the initiation of allergen-induced T helper type 2 responses

被引:726
作者
Sokol, Caroline L. [1 ]
Barton, Gregory M. [2 ]
Farr, Andrew G. [3 ]
Medzhitov, Ruslan [1 ]
机构
[1] Yale Univ, Sch Med, Immunobiol Sect, Howard Hughes Med Inst, New Haven, CT 06510 USA
[2] Univ Calif Berkeley, Dept Mol Cell Biol, Berkeley, CA 94720 USA
[3] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
关键词
D O I
10.1038/ni1558
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Both metazoan parasites and simple protein allergens induce T helper type 2 (T(H)2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown. In addition, the cellular source of cytokines that control T(H)2 differentiation in vivo has not been defined. Here we showed that basophils were activated and recruited to the draining lymph nodes specifically in response to T(H)2-inducing allergen challenge. Furthermore, we demonstrate that the basophil was the accessory cell type required for T(H)2 induction in response to protease allergens. Finally, we show that basophils were directly activated by protease allergens and produced T(H)2-inducing cytokines, including interleukin 4 and thymic stromal lymphopoietin, which are involved in T(H)2 differentiation in vivo.
引用
收藏
页码:310 / 318
页数:9
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