Progress in understanding reprogramming to the induced pluripotent state

被引：215

作者：

Plath, Kathrin ^{[1
,2
,3
,4
]}

Lowry, William E. ^{[2
,3
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90024 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; HUMAN SOMATIC-CELLS; IPS CELLS; TRANSCRIPTIONAL NETWORK; HUMAN FIBROBLASTS; DEFINED FACTORS; X-INACTIVATION; C-MYC; GENERATION; MOUSE;

D O I：

10.1038/nrg2955

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Induction of pluripotency by transcription factors has become a commonplace method to produce pluripotent stem cells. Great strides have been made in our understanding of the mechanism by which this occurs - particularly in terms of transcriptional and chromatin-based events - yet only a small part of the complete picture has been revealed. Understanding the mechanism of reprogramming to pluripotency will have important implications for improving the efficiency and quality of reprogramming and advancing therapeutic application of induced pluripotent stem cells. It will also help to reveal the machinery that stabilizes cell identity and to instruct the design of directed differentiation or lineage switching strategies. To inform the next phase in understanding reprogramming, we review the latest findings, highlight ongoing debates and outline future challenges.

引用

页码：253 / 265

页数：13

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