Genetics and infertility II - Affected sib-pair analysis in endometriosis

被引:43
作者
Kennedy, S
Bennett, S
Weeks, DE
机构
[1] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England
[2] Oxagen Ltd, Oxford, England
[3] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15260 USA
基金
英国惠康基金; 英国医学研究理事会;
关键词
affected sib-pair analysis; endometriosis; genetics; phenotype-genotype; positional cloning;
D O I
10.1093/humupd/7.4.411
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.
引用
收藏
页码:411 / 418
页数:8
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