Genetics and infertility II - Affected sib-pair analysis in endometriosis

被引：43

作者：

Kennedy, S

Bennett, S

Weeks, DE

机构：

[1] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England

[2] Oxagen Ltd, Oxford, England

[3] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15260 USA

来源：

HUMAN REPRODUCTION UPDATE | 2001年 / 7卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

affected sib-pair analysis; endometriosis; genetics; phenotype-genotype; positional cloning;

D O I：

10.1093/humupd/7.4.411

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.

引用

收藏

页码：411 / 418

页数：8

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