Epileptiform activity in rat hippocampus strengthens excitatory synapses

被引：76

作者：

Abegg, MH ^{[1
]}

Savic, N ^{[1
]}

Ehrengruber, MU ^{[1
]}

McKinney, RA ^{[1
]}

Gähwiler, BH ^{[1
]}

机构：

[1] Univ Zurich, Inst Brain Res, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2004年 / 554卷 / 02期

关键词：

D O I：

10.1113/jphysiol.2003.052662

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although epileptic seizures are characterized by excessive excitation, the role of excitatory synaptic transmission in the induction and expression of epilepsy remains unclear. Here, we show that epileptiform activity strengthens excitatory hippocampal synapses by increasing the number of functional (RS)-alpha-amino-3hydroxy-5methyl-4-isoxadepropionate (AMPA)-type glutamate receptors in CA3-CA1 synapses. This form of synaptic strengthening occludes long-term potentiation (LTP) and enhances long-term depression (LTD), processes involved in learning and memory. These changes in synaptic transmission and plasticity, which are fully blocked with N-methyl-D-aspartate (NMDA) receptor antagonists, may underlie epilepsy induction and seizure-associated memory deficits.

引用

页码：439 / 448

页数：10

共 40 条

[1] PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].

不详 .

EPILEPSIA, 1989, 30 (04) :389-399

[2] Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses [J].

Bains, JS ;

Longacher, JM ;

Staley, KJ .

NATURE NEUROSCIENCE, 1999, 2 (08) :720-726

[3] LONG-LASTING MODIFICATION OF THE SYNAPTIC PROPERTIES OF RAT CA3 HIPPOCAMPAL-NEURONS INDUCED BY KAINIC ACID [J].

BENARI, Y ;

GHO, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :365-384

[4] BRIEF SEIZURE EPISODES INDUCE LONG-TERM POTENTIATION AND MOSSY FIBER SPROUTING IN THE HIPPOCAMPUS [J].

BENARI, Y ;

REPRESA, A .

TRENDS IN NEUROSCIENCES, 1990, 13 (08) :312-318

[5] LONG-TERM POTENTIATION INDUCED BY PHYSIOLOGICALLY RELEVANT STIMULUS PATTERNS [J].

BUZSAKI, G ;

HAAS, HL ;

ANDERSON, EG .

BRAIN RESEARCH, 1987, 435 (1-2) :331-333

[6] AN EXAMINATION OF THE RELATIONS BETWEEN HIPPOCAMPAL LONG-TERM POTENTIATION, KINDLING, AFTERDISCHARGE, AND PLACE LEARNING IN THE WATER MAZE [J].

CAIN, DP ;

HARGREAVES, EL ;

BOON, F ;

DENNISON, Z .

HIPPOCAMPUS, 1993, 3 (02) :153-164

[7] EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46

[8] INHIBITION OF THE DEVELOPMENT OF ELECTRICAL KINDLING OF THE PREPYRIFORM CORTEX BY DAILY FOCAL INJECTIONS OF EXCITATORY AMINO-ACID ANTAGONISTS [J].

CROUCHER, MJ ;

BRADFORD, HF ;

SUNTER, DC ;

WATKINS, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 152 (1-2) :29-38

[9] The process of epileptogenesis: a pathophysiological approach [J].

Dalby, NO ;

Mody, I .

CURRENT OPINION IN NEUROLOGY, 2001, 14 (02) :187-192

[10] Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: Quantal fluctuation affects subsequent release [J].

Debanne, D ;

Guerineau, NC ;

Gahwiler, BH ;

Thompson, SM .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 491 (01) :163-176

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