An improved synthesis of 9-[2-(diethoxyphosphonomethoxy)ethyl]adenine and its analogues with other purine bases utilizing the Mitsunobu reaction

被引：11

作者：

Chen, W

Flavin, MT

Filler, R

Xu, ZQ

机构：

[1] MEDICHEM RES INC, LEMONT, IL 60439 USA

[2] IIT, DEPT CHEM, CHICAGO, IL 60616 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1996年 / 15卷 / 11-12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319608002731

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unprotected adenine, 6-chloropurine, 2,6-diaminopurine, and 2-amino-6-chloropurine have been directly coupled with 2-(diethoxyphosphonomethoxy)ethanol under Mitsunobu reaction conditions to provide acyclic phosphonate nucleotide analogues which are intermediates for antiviral agents such as PMEA.

引用

页码：1771 / 1778

页数：8

共 16 条

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