SYNTHESIS OF MESO-2',3'-DIDEOXY-3'BETA-HYDROXYMETHYL CARBOCYCLIC NUCLEOSIDES AS POTENTIAL ANTIVIRAL DRUGS - UNUSUAL COMPETITIVE 2-O-VERSUS N-1-ALKYLATION OF 3-SUBSTITUTED PYRIMIDINES UNDER MITSUNOBU CONDITIONS

被引：27

作者：

BONNAL, C ^{[1
]}

CHAVIS, C ^{[1
]}

LUCAS, M ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,F-34095 MONTPELLIER 5,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 11期

关键词：

D O I：

10.1039/p19940001401

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of meso-2',3'-dideoxy-3'beta-hydroxymethyl carbocyclic nucleosides as potential antiviral drugs via the alkylation of protected purines and pyrimidines with meso-beta,beta'-disubstituted cyclopentanols under Mitsunobu conditions is described. Chemical evidence for an unusual competitive 2-O vs. N-1-alkylation of 3-substituted pyrimidines is presented.

引用

页码：1401 / 1410

页数：10

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