Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

被引：8

作者：

Fei, XS

Zheng, QH ^{[1
]}

Wang, JQ

Stone, KL

Martinez, TD

Miller, KD

Sledge, GW

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.bmcl.2003.12.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Radiolabeled antimitotic agents [C-11]T138067 and [F-18]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [C-11]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [C-11]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1247 / 1251

页数：5

共 24 条

[21] Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents [J].

Zheng, QH ;

Fei, XS ;

Liu, X ;

Wang, JQ ;

Sun, HB ;

Mock, BH ;

Stone, KL ;

Martinez, TD ;

Miller, KD ;

Sledge, GW ;

Hutchins, GD .

NUCLEAR MEDICINE AND BIOLOGY, 2002, 29 (07) :761-770

[22] Improved synthesis of beta-CIT and [C-11]beta-CIT labeled at nitrogen or oxygen positions [J].

Zheng, QH ;

Mulholland, GK .

NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (08) :981-986

[23]

Zheng Qi-Huang, 1997, Journal of Labelled Compounds and Radiopharmaceuticals, V40, P548

[24]

Zheng Qi-Huang, 1997, Journal of Labelled Compounds and Radiopharmaceuticals, V40, P551

← 1 2 3 →