Predictive genetic testing for Alzheimer's disease: Impact upon risk perception

被引:37
作者
Marteau, TM
Roberts, S
LaRusse, S
Green, RC
机构
[1] Kings Coll London, Inst Psychiat, Psychol & Genet Res Grp, London SE1 9RT, England
[2] Boston Univ, Sch Med, Alzheimers Dis Ctr, Boston, MA 02118 USA
[3] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY USA
[4] Boston Univ, Sch Med, Genet Program, Boston, MA 02118 USA
[5] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA
关键词
Alzheimer's disease; genetic testing; risk perception;
D O I
10.1111/j.1539-6924.2005.00598.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The aim of this study was to determine the impact on risk perceptions of disclosing genetic test results used to estimate the risk of Alzheimer's disease (AD). Adult children (n= 149) of people with AD were randomized to one of two groups-Intervention group: lifetime risk estimates of AD based on age, gender, family history, and Apolipoprotein E (APOE) genotype; Control group: lifetime risk estimates of AD based on the same risk factors excluding APOE genotype. Perceptions of personal risk (PPR) for AD were assessed six weeks after risk assessments. PPR were correlated with actual lifetime risk estimates (r= 0.501; p < 0.0001). After controlling for lifetime risks communicated to participants, age, and number of affected relatives, PPR scores among those with an epsilon 4-positive test result (the test result associated with increased AD susceptibility) (adjusted mean: 3.4 (SD: 0.7)) were not different from the PPR scores in the Control group (adjusted mean: 3.4 (SD: 0.7) (F-(1,F-91)= 1.98; p= 0.162). Again, controlling for lifetime risk estimates, age, and number of affected relatives, the PPR score of those receiving an epsilon 4-negative test result was significantly lower (adjusted mean: 3.1 (SD: 0.8)) than those in the Control group (adjusted mean: 3.4 (SD: 0.7) (F-(1,F-95)= 6.23; p= 0.014). Perceptions of risk of developing AD are influenced by genetic test disclosure in those receiving epsilon 4-negative, but not those receiving epsilon 4-positive test results. Despite the reduced perceptions of risk in the former group, there was no evidence of false reassurance (i.e., perceiving risks as equal to or lower than population risks of AD), although this possibility should be assessed in other testing contexts.
引用
收藏
页码:397 / 404
页数:8
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